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Mariner 10 was the first spacecraft to make use of an interplanetary gravitational slingshot maneuver, using Venus to bend its flight path and bring its perihelion down to the level of Mercury's orbit. This maneuver, inspired by the orbital mechanics calculations of the Italian scientist Giuseppe Colombo, put the spacecraft into an orbit that repeatedly brought it back to Mercury. Mariner 10 used the solar radiation pressure on its solar panels and its high-gain antenna as a means of attitude control during flight, the first spacecraft to use active solar pressure control. The components on Mariner 10 can be categorized into four groups based on their common function. The solar panels, power subsystem, attitude control subsystem, and the computer kept the spacecraft operating properly during the flight. The navigational system, including the hydrazine rocket, would keep Mariner 10 on track to Venus and Mercury. Several scientific instruments would collect data at the two planets. Finally, the antennas would transmit this data to the Deep Space Network back on Earth, as well as receive commands from Mission Control. Mariner 10's various components and scientific instruments were attached to a central hub, which was roughly the shape of an octagonal prism. The hub stored the spacecraft's internal electronics. The Mariner 10 spacecraft was manufactured by Boeing. NASA set a strict limit of US$98 million for Mariner 10's total cost, which marked the first time the agency subjected a mission to an inflexible budget constraint. No overruns would be tolerated, so mission planners carefully considered cost efficiency when designing the spacecraft's instruments. Cost control was primarily accomplished by executing contract work closer to the launch date than was recommended by normal mission schedules, as reducing the length of available work time increased cost efficiency. Despite the rushed schedule, very few deadlines were missed. The mission ended up about US$1 million under budget.

Columbia was named after the American sloop Columbia Rediviva which, from 1787 to 1793, under the command of Captain Robert Gray, explored the US Pacific Northwest and became the first American vessel to circumnavigate the globe. It is also named after the command module of Apollo 11, the first crewed landing on another celestial body. Columbia was also the female symbol of the United States. After construction, the orbiter arrived at Kennedy Space Center on March 25, 1979, to prepare for its first launch. Columbia was originally scheduled to lift off in late 1979, however the launch date was delayed by problems with both the RS-25 engine, as well as the thermal protection system. The first flight of Columbia was commanded by John Young, a veteran from the Gemini and Apollo programs who was the ninth person to walk on the Moon in 1972, and piloted by Robert Crippen, a rookie astronaut originally selected to fly on the military's Manned Orbital Laboratory spacecraft, but transferred to NASA after its cancellation, and served as a support crew member for the Skylab and Apollo-Soyuz missions. Columbia spent 610 days in the Orbiter Processing Facility, another 35 days in the Vehicle Assembly Building, and 105 days on Pad 39A before finally lifting off. It was successfully launched on April 12, 1981, the 20th anniversary of the first human spaceflight (Vostok 1), and returned on April 14, 1981, after orbiting the Earth 36 times, landing on the dry lakebed runway at Edwards Air Force Base in California. It then undertook three further research missions to test its technical characteristics and performance. Its first operational mission, with a four-man crew, launched on November 11, 1982. At this point Columbia was joined by Challenger, which flew the next three shuttle missions, while Columbia underwent modifications for the first Spacelab mission. In 1983, Columbia, under the command of John Young on what was his sixth spaceflight, undertook its second operational mission, in which the Spacelab science laboratory and a six-person crew was carried, including the first non-American astronaut on a space shuttle, Ulf Merbold. After the flight, it spent 18 months at the Rockwell Palmdale facility beginning in January 1984, undergoing modifications that removed the Orbiter Flight Test hardware and updating it to similar specifications as those of its sister orbiters.